Antiviral Responses by Swine Primary Bronchoepithelial Cells Are Limited Compared to Human Bronchoepithelial Cells Following Influenza Virus Infection
Identifieur interne : 000916 ( Main/Exploration ); précédent : 000915; suivant : 000917Antiviral Responses by Swine Primary Bronchoepithelial Cells Are Limited Compared to Human Bronchoepithelial Cells Following Influenza Virus Infection
Auteurs : Mary J. Hauser [États-Unis] ; Daniel Dlugolenski [États-Unis] ; Marie R. Culhane [États-Unis] ; David E. Wentworth [États-Unis] ; S. Mark Tompkins [États-Unis] ; Ralph A. Tripp [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2013.
Abstract
Swine generate reassortant influenza viruses because they can be simultaneously infected with avian and human influenza; however, the features that restrict influenza reassortment in swine and human hosts are not fully understood. Type I and III interferons (IFNs) act as the first line of defense against influenza virus infection of respiratory epithelium. To determine if human and swine have different capacities to mount an antiviral response the expression of IFN and IFN-stimulated genes (ISG) in normal human bronchial epithelial (NHBE) cells and normal swine bronchial epithelial (NSBE) cells was evaluated following infection with human (H3N2), swine (H1N1), and avian (H5N3, H5N2, H5N1) influenza A viruses. Expression of IFNλ and ISGs were substantially higher in NHBE cells compared to NSBE cells following H5 avian influenza virus infection compared to human or swine influenza virus infection. This effect was associated with reduced H5 avian influenza virus replication in human cells at late times post infection. Further, RIG-I expression was lower in NSBE cells compared to NHBE cells suggesting reduced virus sensing. Together, these studies identify key differences in the antiviral response between human and swine respiratory epithelium alluding to differences that may govern influenza reassortment.
Url:
DOI: 10.1371/journal.pone.0070251
PubMed: 23875024
PubMed Central: 3707852
Affiliations:
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Tripp</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Swine generate reassortant influenza viruses because they can be simultaneously infected with avian and human influenza; however, the features that restrict influenza reassortment in swine and human hosts are not fully understood. Type I and III interferons (IFNs) act as the first line of defense against influenza virus infection of respiratory epithelium. To determine if human and swine have different capacities to mount an antiviral response the expression of IFN and IFN-stimulated genes (ISG) in normal human bronchial epithelial (NHBE) cells and normal swine bronchial epithelial (NSBE) cells was evaluated following infection with human (H3N2), swine (H1N1), and avian (H5N3, H5N2, H5N1) influenza A viruses. Expression of IFNλ and ISGs were substantially higher in NHBE cells compared to NSBE cells following H5 avian influenza virus infection compared to human or swine influenza virus infection. This effect was associated with reduced H5 avian influenza virus replication in human cells at late times post infection. Further, RIG-I expression was lower in NSBE cells compared to NHBE cells suggesting reduced virus sensing. Together, these studies identify key differences in the antiviral response between human and swine respiratory epithelium alluding to differences that may govern influenza reassortment.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Robertson, Js" uniqKey="Robertson J">JS Robertson</name></author><author><name sortKey="Inglis, Sc" uniqKey="Inglis S">SC Inglis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Trifonov, V" uniqKey="Trifonov V">V Trifonov</name></author><author><name sortKey="Khiabanian, H" uniqKey="Khiabanian H">H Khiabanian</name></author><author><name sortKey="Rabadan, R" uniqKey="Rabadan R">R Rabadan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carrat, F" uniqKey="Carrat F">F Carrat</name></author><author><name sortKey="Flahault, A" uniqKey="Flahault A">A Flahault</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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sortKey="Burmakina, S" uniqKey="Burmakina S">S Burmakina</name></author><author><name sortKey="Moran, T" uniqKey="Moran T">T Moran</name></author><author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A García-Sastre</name></author><author><name sortKey="Fernandez Sesma, A" uniqKey="Fernandez Sesma A">A Fernandez-Sesma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Honda, K" uniqKey="Honda K">K Honda</name></author><author><name sortKey="Taniguchi, T" uniqKey="Taniguchi T">T Taniguchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nelli, Rk" uniqKey="Nelli R">RK Nelli</name></author><author><name sortKey="Dunham, Sp" uniqKey="Dunham S">SP Dunham</name></author><author><name sortKey="Kuchipudi, Sv" uniqKey="Kuchipudi S">SV Kuchipudi</name></author><author><name sortKey="White, Ga" uniqKey="White G">GA White</name></author><author><name sortKey="Baquero Perez, B" uniqKey="Baquero Perez B">B Baquero-Perez</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li><li>Maryland</li><li>Minnesota</li></region></list><tree><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Hauser, Mary J" sort="Hauser, Mary J" uniqKey="Hauser M" first="Mary J." last="Hauser">Mary J. Hauser</name></region><name sortKey="Culhane, Marie R" sort="Culhane, Marie R" uniqKey="Culhane M" first="Marie R." last="Culhane">Marie R. Culhane</name><name sortKey="Dlugolenski, Daniel" sort="Dlugolenski, Daniel" uniqKey="Dlugolenski D" first="Daniel" last="Dlugolenski">Daniel Dlugolenski</name><name sortKey="Tompkins, S Mark" sort="Tompkins, S Mark" uniqKey="Tompkins S" first="S. Mark" last="Tompkins">S. Mark Tompkins</name><name sortKey="Tripp, Ralph A" sort="Tripp, Ralph A" uniqKey="Tripp R" first="Ralph A." last="Tripp">Ralph A. Tripp</name><name sortKey="Wentworth, David E" sort="Wentworth, David E" uniqKey="Wentworth D" first="David E." last="Wentworth">David E. Wentworth</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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